Description

α-Conotoxin Imi is a selective and potent peptide neurotoxin derived from the venom of marine cone snails. This compound is a valuable research tool for studying and characterizing nicotinic acetylcholine receptors (nAChRs), particularly the α3β2 and α7 subtypes. It is essential for neuroscience and pharmacological research focused on receptor function, neurological pathways, and potential therapeutic targets.

Application

• Neuroscience Research: A key pharmacological tool for the selective blockade and study of neuronal nicotinic acetylcholine receptors (nAChRs).
• Receptor Subtype Characterization: Used to distinguish between and investigate the functional roles of α3β2 and α7 nAChR subtypes in various tissues.
• Ion Channel Studies: Facilitates research into ion channel physiology, synaptic transmission, and neuronal signaling pathways.
• Drug Discovery & Development: Serves as a reference compound and probe in screening assays for developing novel analgesics or neurological therapeutics.
• Biochemical Assays: Employed in competitive binding studies and functional assays to understand ligand-receptor interactions.
• Academic & Pharmaceutical R&D: Critical for basic research and pre-clinical studies in university, biotech, and pharmaceutical laboratory settings.

Basic Information

Product Name	α-Conotoxin Imi
CAS No.	156467-85-5
Molecular Formula	C58H86N18O16S4
Molecular Weight	1387.6 g/mol
Synonyms	α-Conotoxin ImI; Conotoxin ImI; α-Conotoxin ImI; ImI Conotoxin; α-ImI; α-ImI; Conus imperialis toxin ImI; Nicotinic Acetylcholine Receptor Antagonist ImI
EINECS	Contact for details

Quality Control

Our α-Conotoxin Imi is produced and tested under stringent quality management protocols to ensure high purity, batch-to-batch consistency, and biological activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and bioactivity data. We adhere to relevant standards for research-grade biochemicals to support reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Biological Activity (IC50)	Specified per batch (typically nM range vs. α7 nAChR)
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.