Description

1H-Pyrrolizine-3-Acetonitrile, Hexahydro-1,2,7-Trihydroxy-, 1R-(1.Alpha.,2.Beta.,3.Alpha.,7.Beta.,7A.Alpha.)- is a high-purity, stereochemically defined synthetic intermediate of significant interest in advanced organic synthesis. Its complex polyhydroxylated pyrrolizine structure makes it a valuable chiral building block for pharmaceutical research and development. This compound is primarily sought after by R&D chemists and process development scientists in the fine chemical and pharmaceutical industries for constructing novel active pharmaceutical ingredients (APIs) and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of potential drug candidates targeting neurological and metabolic disorders.
• Asymmetric Synthesis: Utilized as a sophisticated building block for constructing complex molecules with multiple stereocenters via advanced organic reactions.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs due to its unique polyfunctionalized scaffold.
• Process Chemistry Development: Used in scaling up synthetic routes for novel compounds, requiring high chemical and stereochemical purity.
• Fine Chemical Production: Acts as a specialized intermediate for custom synthesis and contract manufacturing organizations (CMOs).
• Academic Research: Applied in university and institutional labs for methodological development in total synthesis and heterocyclic chemistry.

Basic Information

Item	Details
Product Name	1H-Pyrrolizine-3-Acetonitrile, Hexahydro-1,2,7-Trihydroxy-, 1R-(1.Alpha.,2.Beta.,3.Alpha.,7.Beta.,7A.Alpha.)-
CAS No.	156205-60-6
Molecular Formula	C9H14N2O3
Molecular Weight	198.22 g/mol
Synonyms	(1R,2R,3R,7S,7aR)-Hexahydro-1,2,7-trihydroxy-1H-pyrrolizine-3-acetonitrile; Hexahydro-1,2,7-trihydroxy-1H-pyrrolizine-3-acetonitrile (1R-(1α,2β,3α,7β,7aα))-; 1H-Pyrrolizine-3-acetonitrile, hexahydro-1,2,7-trihydroxy-, (1R,2R,3R,7S,7aR)-; 156205-60-6; Pyrrolizine acetonitrile derivative; Chiral pyrrolizine nitrile.
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolizine-3-Acetonitrile, Hexahydro-1,2,7-Trihydroxy-, 1R-(1.Alpha.,2.Beta.,3.Alpha.,7.Beta.,7A.Alpha.)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high stereochemical purity, critical for sensitive synthetic applications. All products undergo rigorous analytical testing including HPLC, chiral analysis, and NMR to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.