Description

3-Chloro-4-Fluoroiodobenzene is a high-purity halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique combination of chlorine, fluorine, and iodine substituents on the benzene ring makes it a versatile intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought after by research chemists and process development scientists for applications in cross-coupling reactions, such as Suzuki and Negishi couplings, and for the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those requiring halogenated aromatic cores for bioactivity or further functionalization.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the specific halogen pattern influences biological activity and environmental stability.
• Material Science Research: Serves as a monomer or building block for creating specialized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki-Miyaura, Stille, Sonogashira) to form biaryl structures, which are common motifs in many functional molecules.
• Chemical Synthesis & Derivatization: The iodine moiety allows for further selective transformations, making it a versatile starting point for creating a library of derivatives for screening and optimization.

Basic Information

Item	Detail
Product Name	3-Chloro-4-Fluoroiodobenzene
CAS No.	156150-67-3
Molecular Formula	C6H3ClFI
Molecular Weight	256.44 g/mol
Synonyms	1-Chloro-2-fluoro-4-iodobenzene; 4-Iodo-3-chlorofluorobenzene; 3-Chloro-4-fluoro-1-iodobenzene; 2-Fluoro-5-iodochlorobenzene; (3-Chloro-4-fluorophenyl)iodide; Benzene, 1-chloro-2-fluoro-4-iodo-; Iodobenzene, 3-chloro-4-fluoro-
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Fluoroiodobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting purity, assay, and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.