Description

(Trp6)-Lhrh CAS NO 156126-74-8 is a synthetic peptide analog of Luteinizing Hormone-Releasing Hormone (LHRH), modified at the sixth position with tryptophan. This modification is significant for research into hormone-receptor interactions and the development of targeted therapeutic agents. It is primarily utilized by pharmaceutical R&D teams and academic researchers in the fields of endocrinology, oncology, and reproductive medicine for studying hormone signaling pathways and peptide stability.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel LHRH-based therapeutics.
• Endocrinology Studies: Used in biochemical assays to investigate the structure-activity relationship (SAR) of LHRH and its interaction with gonadotropin-releasing hormone (GnRH) receptors.
• Oncology Research: Employed in preclinical studies for cancers that are hormone-sensitive, exploring the potential of modified LHRH analogs in targeted therapy.
• Reproductive Medicine: Applied in research focused on fertility treatments and the regulation of the hypothalamic-pituitary-gonadal axis.
• Peptide Chemistry & Stability Testing: Acts as a model compound for studying the effects of specific amino acid substitutions on peptide stability, solubility, and bioavailability.
• Bioconjugation & Probe Development: Utilized as a base structure for creating labeled probes (e.g., fluorescent, radioactive) for diagnostic assay development and receptor mapping.

Basic Information

Product Name	(Trp6)-Lhrh
CAS No.	156126-74-8
Molecular Formula	C64H83N17O13
Molecular Weight	1266.5 g/mol
Synonyms	(Trp6)-Luteinizing Hormone-Releasing Hormone; (Trp6)-GnRH; (Tryptophan-6)-LHRH; LHRH (6-Tryptophan); Gonadorelin (6-Trp) analog; pGlu-His-Trp-Ser-Tyr-Trp-Leu-Arg-Pro-Gly-NH2; Luteinizing Hormone-Releasing Factor (6-Trp) analog; GnRH agonist/antagonist research compound
EINECS	Contact for details

Quality Control

Our (Trp6)-Lhrh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to reach room temperature before opening to prevent condensation and moisture uptake. For long-term storage, consider desiccant or under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.