Description

(S)-5-(Hydroxymethyl)-3,3-Dimethylpyrrolidin-2-One is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. This compound is valued for its structural role in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic disorders. It is primarily sought after by research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in the development of novel therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules, particularly for central nervous system (CNS) and metabolic disease targets.
• Asymmetric Synthesis: Used as a precursor or auxiliary in catalytic asymmetric reactions to introduce stereochemical complexity.
• Protease Inhibitor Development: Serves as a core structural component in the research and production of protease inhibitors.
• Agrochemical Research: Employed in the development of advanced, chiral active ingredients for crop protection.
• Academic & Industrial R&D: Utilized in medicinal chemistry programs for lead optimization and structure-activity relationship (SAR) studies.
• Peptidomimetics: Acts as a constrained scaffold in the design of peptide mimics to enhance metabolic stability and bioavailability.

Basic Information

Product Name	(S)-5-(Hydroxymethyl)-3,3-Dimethylpyrrolidin-2-One
CAS No.	156088-46-9
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	(S)-5-(Hydroxymethyl)-3,3-dimethyl-2-pyrrolidinone; (3S)-5-(Hydroxymethyl)-3,3-dimethylpyrrolidin-2-one; (S)-3,3-Dimethyl-5-(hydroxymethyl)-2-pyrrolidinone; (S)-3,3-Dimethyl-5-(hydroxymethyl)pyrrolidin-2-one; (S)-5-(Hydroxymethyl)-3,3-dimethylpyrrolidinone; (S)-HMP; (S)-156088-46-9
EINECS	Contact for details

Quality Control

Our (S)-5-(Hydroxymethyl)-3,3-Dimethylpyrrolidin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.