Description

1,2,4-Butanetriol-3-(1,4,7,10-Tetraazacyclododec-1-Yl)4Hydrochloride is a high-purity, functionalized cyclen derivative, a key building block in advanced coordination chemistry. Its primary value lies in its ability to act as a versatile chelating ligand for metal ions, forming stable complexes for targeted applications. This compound is essential for researchers and manufacturers in the pharmaceutical, diagnostic, and materials science sectors, particularly for developing novel contrast agents, radiopharmaceuticals, and catalytic systems.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of macrocyclic chelators for gadolinium-based MRI contrast agents.
• Radiopharmaceutical Development: Used to create bifunctional chelators for labeling peptides and antibodies with diagnostic or therapeutic radioisotopes (e.g., 68Ga, 177Lu).
• Catalysis Research: Serves as a ligand scaffold for designing homogeneous catalysts in organic synthesis and polymerization processes.
• Chemical Sensor Fabrication: Incorporated into sensor materials for the selective detection of metal ions or small molecules.
• Bioconjugation Chemistry: The functionalized triol arm provides a handle for further chemical modification and conjugation to biomolecules.
• Materials Science: A building block for creating metal-organic frameworks (MOFs) or functional polymers with specific metal-binding properties.

Basic Information

Product Name	1,2,4-Butanetriol-3-(1,4,7,10-Tetraazacyclododec-1-Yl)4Hydrochloride
CAS No.	156077-56-4
Molecular Formula	C14H34Cl4N4O3
Molecular Weight	440.25 g/mol
Synonyms	1,4,7,10-Tetraazacyclododecane-1-(2,3-dihydroxybutyl)-4,7,10-triacetic acid tri-tert-butyl ester trihydrochloride (precursor form); BT-DO3A; Butanetriol-DO3A; 1,2,4-Butanetriol-3-(1,4,7,10-tetraazacyclododecan-1-yl)-4-hydrochloride; Cyclen derivative with butanetriol pendant arm; DO3A-butrol derivative; Ligand for Gd(III) complexation
EINECS	Contact for details

Quality Control

Our 1,2,4-Butanetriol-3-(1,4,7,10-Tetraazacyclododec-1-Yl)4Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets exacting standards for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.