Description

(R,S)-Fmoc-α-Methoxyglycine is a protected non-proteinogenic amino acid derivative, specifically designed for solid-phase peptide synthesis (SPPS). This compound is essential for introducing structural diversity and conformational constraints into synthetic peptides, enabling advanced research in medicinal chemistry and drug discovery. It is a critical building block for pharmaceutical R&D, biotechnology, and academic laboratories focused on developing novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated synthesis of complex peptides containing methoxyglycine residues.
• Peptidomimetic Drug Development: Used to create peptide analogs with enhanced metabolic stability, bioavailability, and target specificity for therapeutic applications.
• Conformational Studies: Incorporation into peptide chains to study the effects of α-alkoxy substitution on secondary structure (e.g., helix, sheet, turn formation).
• Bioconjugation & Labeling: Serves as a versatile intermediate for attaching peptides to other molecules, surfaces, or reporter groups via its carboxylic acid functionality.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse libraries of peptide-like compounds for high-throughput screening against biological targets.
• Academic & Industrial Research: Fundamental research tool in organic synthesis, chemical biology, and proteomics for exploring protein-protein interactions and enzyme mechanisms.

Basic Information

Product Name	(R,S)-Fmoc-α-Methoxyglycine
CAS No.	156059-09-5
Molecular Formula	C19H19NO5
Molecular Weight	341.36 g/mol
Synonyms	Fmoc-Methoxyglycine-OH; N-(9-Fluorenylmethoxycarbonyl)-α-methoxyglycine; 2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-2-methoxyacetic acid; (RS)-Fmoc-α-Methoxyglycine; Fmoc-α-MeO-Gly-OH; Nα-Fmoc-α-methoxyglycine; 2-Methoxy-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]acetic acid
EINECS	Contact for details

Quality Control

Our (R,S)-Fmoc-α-Methoxyglycine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and chiral analysis to verify the racemic mixture. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Optical Rotation	Contact for details
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.