Description

Naloxone-3-Sulfate Sodium Salt is a chemically modified derivative of the opioid antagonist naloxone, specifically designed for enhanced solubility and stability. This compound is critical for advanced pharmaceutical research and development, particularly in the study of opioid receptor pharmacology and the creation of novel drug formulations. It serves as a key reference standard and intermediate for researchers and manufacturers in the pharmaceutical and biotechnology sectors, enabling precise analytical work and the development of next-generation therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the quality control and analytical testing of naloxone-based products in GMP environments.
• Metabolite Research: Essential for studying the metabolic pathways and sulfate-conjugated metabolites of naloxone in pharmacokinetic and ADME studies.
• Drug Discovery Intermediate: Serves as a key synthetic intermediate or precursor in the research and development of new opioid antagonists with modified properties.
• Analytical Chemistry: Employed in method development and validation for HPLC, LC-MS, and other chromatographic techniques in forensic and clinical laboratories.
• Biochemical Assays: Used in in vitro receptor binding assays and other pharmacological studies to investigate opioid receptor interactions.
• Formulation Development: Aids in developing stable injectable or other dosage forms due to its altered physicochemical profile compared to the parent compound.

Basic Information

Product Name	Naloxone-3-Sulfate Sodium Salt
CAS No.	156047-22-2
Molecular Formula	C19H20NNaO7S
Molecular Weight	429.42 g/mol
Synonyms	Naloxone 3-Sulfate Sodium; Naloxone Sulfate Sodium Salt; 17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one 3-Sulfate Sodium Salt; Sodium Naloxone Sulfate; Naloxone Hydrogen Sulfate Sodium Salt; (-)-Naloxone 3-Sulfate Sodium Salt; Naloxone-3-O-sulfate Sodium.
EINECS	Contact for details

Quality Control

Our Naloxone-3-Sulfate Sodium Salt is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity assessment by HPLC to ensure it meets high-purity standards suitable for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.