Description

4-Bromo-2-Cyanobenzyl Bromide is a versatile and high-value brominated aromatic building block essential for advanced organic synthesis. Its bifunctional nature, featuring both a reactive benzyl bromide and a cyano group, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the bromine atom serves as a handle for further functionalization.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized phosphine ligands, N-heterocyclic carbene (NHC) precursors, and other organocatalysts.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and polymers with tailored electronic or photophysical properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Buchwald-Hartwig amination to form biaryl and other complex structures.
• Chemical Biology Probes: Utilized to create tagged molecules or affinity probes for studying biological pathways and target engagement.

Basic Information

Product Name	4-Bromo-2-Cyanobenzyl Bromide
CAS No.	156001-53-5
Molecular Formula	C8H5Br2N
Molecular Weight	274.94 g/mol
Synonyms	2-Cyano-4-bromobenzyl Bromide; 4-Bromo-2-cyanobenzyl Bromide; α-Bromo-4-bromo-2-cyanotoluene; (4-Bromo-2-cyanophenyl)methyl Bromide; 1-(Bromomethyl)-4-bromo-2-cyanobenzene; 2-Cyanobenzyl Bromide, 4-Bromo-; Benzene, 1-(bromomethyl)-4-bromo-2-cyano-
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Cyanobenzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and organic solvents. Due to its light-sensitive nature, handling should be minimized under direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.