Description

(1R,2R)-trans-n-Boc-2-Aminocyclohexanol is a high-purity, chiral building block featuring a protected amino alcohol functionality. This compound is critical for the synthesis of complex molecules where stereochemical integrity is paramount, offering precise control over the final product's three-dimensional structure. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing active pharmaceutical ingredients (APIs), catalysts, and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of drug candidates, particularly for neurological and anti-infective agents.
• Catalyst and Ligand Precursor: Used in the development of chiral catalysts and ligands for enantioselective transformations.
• Peptidomimetic Chemistry: Serves as a constrained scaffold for designing peptide analogs and protease inhibitors.
• Agrochemical Synthesis: Employed in the production of enantiomerically pure herbicides and fungicides.
• Academic and R&D: A valuable reagent for methodological research in organic and medicinal chemistry laboratories.
• Custom Synthesis Building Block: For contract research and manufacturing organizations (CROs/CMOs) producing bespoke fine chemicals.

Basic Information

Product Name	(1R,2R)-trans-n-Boc-2-Aminocyclohexanol
CAS No.	155975-19-2
Molecular Formula	C11H21NO3
Molecular Weight	215.29 g/mol
Synonyms	(1R,2R)-2-[(tert-Butoxycarbonyl)amino]cyclohexanol; (1R,2R)-N-Boc-2-Aminocyclohexanol; trans-N-Boc-2-Aminocyclohexanol; (1R,2R)-1,2-Cyclohexanediol, 2-[(1,1-dimethylethoxy)carbonyl]amino-, (1R,2R)-; tert-Butyl (1R,2R)-2-hydroxycyclohexylcarbamate; BOC-trans-(1R,2R)-2-Aminocyclohexanol; Chiral BOC-protected cyclohexylamine
EINECS	Contact for details

Quality Control

Our (1R,2R)-trans-n-Boc-2-Aminocyclohexanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.