Description

(1S)-1-(Diphenylphosphino)-2-[(1R)-1-(Diphenylphosphino)Ethyl]-Ferrocene is a high-value, chiral ferrocenyl diphosphine ligand, a cornerstone in modern asymmetric catalysis. Its significance lies in its ability to induce high enantioselectivity in a variety of transition metal-catalyzed reactions, enabling the efficient production of single-enantiomer compounds. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for developing new active ingredients and advanced materials.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, critical for synthesizing chiral pharmaceutical intermediates and natural products.
• Asymmetric C-C Bond Formation: Employed in reactions such as cross-coupling, allylic alkylation, and hydroformylation to construct complex chiral molecular architectures with high fidelity.
• Pharmaceutical Intermediate Synthesis: Facilitates the production of enantiomerically pure active pharmaceutical ingredients (APIs) for drugs targeting central nervous system disorders, cardiovascular diseases, and infectious diseases.
• Agrochemical Production: Used in the synthesis of chiral herbicides, fungicides, and pesticides, where the correct stereoisomer is often crucial for biological activity and environmental safety.
• Fine Chemical and Fragrance Manufacturing: Enables the asymmetric synthesis of complex flavor and fragrance compounds, as well as other high-value specialty chemicals.
• Academic and Industrial Catalyst Research: Serves as a key building block for developing new chiral catalyst systems and studying structure-activity relationships in catalysis.

Basic Information

Item	Details
Product Name	(1S)-1-(Diphenylphosphino)-2-[(1R)-1-(Diphenylphosphino)Ethyl]-Ferrocene
CAS No.	155941-31-4
Molecular Formula	C36H32FeP2
Molecular Weight	582.43 g/mol
Synonyms	(S,R)-JOSIPHOS; (S)-1-[(R)-2-(Diphenylphosphino)ferrocenyl]ethyldiphenylphosphine; (S)-1-[(R)-1',2-Bis(diphenylphosphino)ferrocenyl]ethane; (S)-1-[(R)-1',2-Bis(diphenylphosphino)ferrocenyl]ethyl; JOSIPHOS SL-J009-1; JOSIPHOS ligand; (1S)-1-(Diphenylphosphino)-2-[(1R)-1-(diphenylphosphino)ethyl]ferrocene
EINECS	Contact for details

Quality Control

Our (1S)-1-(Diphenylphosphino)-2-[(1R)-1-(Diphenylphosphino)Ethyl]-Ferrocene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and metal content analysis, to ensure it meets the high standards required for sensitive catalytic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific tests is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized and moisture-sensitive; therefore, the container should be purged with inert gas before resealing after each use. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.