Description

2-Bromo-1,3-Difluoro-5-Iodobenzene is a highly functionalized halogenated benzene derivative, serving as a critical multi-purpose building block in advanced organic synthesis. Its unique combination of bromo, fluoro, and iodo substituents on the aromatic ring makes it exceptionally valuable for introducing halogen atoms and enabling subsequent cross-coupling reactions. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating complex molecules and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores for bioactivity or further functionalization.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the difluoro and iodo groups contribute to specific biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or building block for synthesizing specialized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Sonogashira couplings, leveraging the reactive iodo and bromo groups for sequential functionalization.
• Fluorinated Compound Libraries: Integral for medicinal chemistry programs focused on creating fluorinated compound libraries to explore structure-activity relationships.
• Ligand and Catalyst Development: Used in the preparation of complex ligands and organometallic catalysts for asymmetric synthesis.

Basic Information

Product Name	2-Bromo-1,3-Difluoro-5-Iodobenzene
CAS No.	155906-10-8
Molecular Formula	C6H2BrF2I
Molecular Weight	318.89 g/mol
Synonyms	1-Bromo-2,4-difluoro-6-iodobenzene; 2,4-Difluoro-6-iodobromobenzene; Benzene, 2-bromo-1,3-difluoro-5-iodo-; 5-Iodo-2-bromo-1,3-difluorobenzene; 2-Bromo-5-iodo-1,3-difluorobenzene; 1,3-Difluoro-2-bromo-5-iodobenzene
EINECS	Contact for details

Quality Control

Our 2-Bromo-1,3-Difluoro-5-Iodobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.