Description

(+)-n-Trifluoroacetyl-L-Phenylglycine CAS NO 155894-96-5 is a high-purity, enantiomerically pure chiral building block and derivatizing agent. This compound is critical for the synthesis and resolution of optically active pharmaceuticals and fine chemicals, ensuring high stereochemical fidelity. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors for developing active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of active pharmaceutical ingredients (APIs), particularly for antibiotics and neurological drugs.
• Chiral Derivatizing Agent: Used for the resolution of racemic mixtures via diastereomeric salt formation or chromatography to obtain enantiomerically pure compounds.
• Peptide Synthesis: Serves as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis.
• Agrochemical Research: Employed in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Preparation: A precursor for synthesizing chiral ligands and organocatalysts used in asymmetric catalysis.
• Analytical Reference Standard: Used as a high-purity standard in HPLC and LC-MS for method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	(+)-n-Trifluoroacetyl-L-Phenylglycine
CAS No.	155894-96-5
Molecular Formula	C11H10F3NO3
Molecular Weight	261.20 g/mol
Synonyms	(S)-2-(Trifluoroacetamido)-2-phenylacetic acid; L-α-Phenylglycine, N-trifluoroacetyl-; N-Trifluoroacetyl-L-phenylglycine; (S)-N-Trifluoroacetyl-2-phenylglycine; (+)-N-Trifluoroacetyl-L-2-phenylglycine; TFA-L-Phenylglycine; (S)-2-Phenyl-2-[(trifluoroacetyl)amino]acetic acid
EINECS	Contact for details

Quality Control

Our (+)-n-Trifluoroacetyl-L-Phenylglycine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high enantiomeric excess (ee) and chemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.