Description

Heregulin Beta1 is a recombinant human growth factor protein that plays a critical role in cellular signaling pathways. This high-purity protein is essential for advanced life science research and biopharmaceutical development, particularly in the study of receptor tyrosine kinases and cell proliferation. It is primarily utilized by researchers and manufacturers in the fields of oncology, neurology, and regenerative medicine for applications such as cell culture, assay development, and target validation.

Application

• Cell Culture & Differentiation Studies: Used to stimulate the growth and differentiation of specific cell lines, particularly those expressing the ErbB3/ErbB4 receptors.
• Oncology Research: Serves as a key ligand in studying the HER/ErbB signaling pathways involved in cancer cell growth and metastasis.
• Neurological Research: Applied in studies of neuronal development, survival, and synaptic plasticity due to its role in the nervous system.
• Assay Development: Acts as a critical component in bioassays and high-throughput screening (HTS) platforms for drug discovery.
• Receptor Binding & Signal Transduction Studies: Utilized to investigate ligand-receptor interactions and downstream signaling cascades.
• Biopharmaceutical Reference Standard: Employed as a quality control standard in the production and testing of related therapeutic proteins.

Basic Information

Product Name	Heregulin Beta1
CAS No.	155646-83-6
Molecular Formula	C644H1006N176O198S10
Molecular Weight	~14.5 kDa
Synonyms	Recombinant Human Heregulin-β1 EGF Domain; HRG1-β1 EGF; HRG-beta1; Neuregulin-1 Beta 1; NRG1-β1; NDNF; ARIA; GGF; SMDF; Neu Differentiation Factor; Acetylcholine Receptor-Inducing Activity; Glial Growth Factor; Sensory and Motor Neuron-Derived Factor
EINECS	Contact for details

Quality Control

Our Heregulin Beta1 is produced under stringent conditions and undergoes rigorous analytical testing to ensure the highest standards of purity and biological activity. Each lot is characterized using techniques including SDS-PAGE, HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing purity, endotoxin levels, and biological activity are provided to guarantee consistency and reliability for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, it is recommended to keep the lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Purity (SDS-PAGE)	≥ 95%
Purity (HPLC)	≥ 98.0%
Molecular Weight	~14.5 kDa (by SDS-PAGE under reducing conditions)
Endotoxin Level	< 1.0 EU/μg
Biological Activity	Determined by cell proliferation assay
Identification (Mass Spectrometry)	Consistent with theoretical average mass
Solubility	Soluble in water or PBS

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.