Description

Perphenazine-D4 (Phenothiazine-1,3,7,9-D4) is a deuterium-labeled analog of the antipsychotic drug Perphenazine, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, such as LC-MS/MS. It is a critical tool for researchers and quality control laboratories in the pharmaceutical and forensic toxicology sectors who require precise quantification of Perphenazine in complex biological matrices.

Application

• Internal Standard for Bioanalysis: Primary use as a deuterated internal standard in the quantification of Perphenazine in plasma, serum, and urine via LC-MS/MS and GC-MS.
• Pharmaceutical R&D: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies, metabolism research, and drug development for accurate tracer analysis.
• Forensic and Clinical Toxicology: Enables precise measurement of Perphenazine levels in forensic investigations and therapeutic drug monitoring (TDM) programs.
• Method Development and Validation: Critical for developing, validating, and ensuring the robustness of analytical methods in compliance with FDA and ICH guidelines.
• Reference Material: Serves as a certified reference material (CRM) for calibrating instruments and verifying analytical procedures in quality control laboratories.

Basic Information

Product Name	Perphenazine-D4 (Phenothiazine-1,3,7,9-D4)
CAS No.	155593-75-2
Molecular Formula	C₂₁H₂₂D₄ClN₃OS
Molecular Weight	~408.0 g/mol
Synonyms	Perphenazine-d4; 2-[4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethanol-d4; 1,3,7,9-Tetradeutero-perphenazine; 4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol-d4; Deuterated Perphenazine; Perphenazine Internal Standard; DSM-IV; Trilafon-d4
EINECS	Contact for details

Quality Control

Our Perphenazine-D4 is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (≥98% D), chemical purity (by HPLC), and confirmation of structure (by NMR and MS). We support compliance with GMP and ISO 17034 standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. Keep the container in a dry, cool, and well-ventilated place. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Chemical Purity	≥95%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.