Description

Ethanamine, 2-((6,11-Dihydro-6-Methyldibenzo(C,F)Thiazepin-11-Yl)Oxy)- n-Methyl-, 5,5-Dioxide(Z)-2-Butenedioate (1:1) is a high-purity, non-racemic pharmaceutical intermediate and active ingredient. This compound matters for its critical role in the synthesis of advanced therapeutic agents, offering a reliable and consistent building block for complex molecular architectures. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel central nervous system (CNS) and psychotropic medications.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel dibenzothiazepine-derived active pharmaceutical ingredients (APIs).
• Neurological Research: Used in preclinical and clinical research for developing potential treatments targeting specific CNS receptors.
• Process Chemistry: Serves as a critical chiral intermediate in scale-up and optimization of synthetic routes for complex drug molecules.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical manufacturing.
• Asymmetric Synthesis: Utilized in the preparation of enantiomerically pure compounds for pharmacological evaluation.

Basic Information

Product Name	Ethanamine, 2-((6,11-Dihydro-6-Methyldibenzo(C,F)Thiazepin-11-Yl)Oxy)- n-Methyl-, 5,5-Dioxide(Z)-2-Butenedioate (1:1)
CAS No.	155444-07-8
Molecular Formula	C21H22N2O7S
Molecular Weight	446.48 g/mol
Synonyms	Quetiapine Fumarate; Quetiapine Hemifumarate; (11-{4-[2-(2-Hydroxyethoxy)ethyl]-1-piperazinyl}dibenzo[b,f][1,4]thiazepine) Fumarate; ICI 204,636 Fumarate; Seroquel Fumarate; 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol fumarate; Z-2-Butenedioic acid compound with 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-1-yl)ethoxy]ethanol (1:1)
EINECS	Contact for details

Quality Control

Our Ethanamine, 2-((6,11-Dihydro-6-Methyldibenzo(C,F)Thiazepin-11-Yl)Oxy)- n-Methyl-, 5,5-Dioxide(Z)-2-Butenedioate (1:1) is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including chiral HPLC, to ensure compliance with pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each batch to support regulatory filings and GMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F), in a dry environment. The product is hygroscopic (moisture-sensitive) and should be handled under conditions of low humidity to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.