Description

3-Amino-2,2-difluoropropan-1-ol is a valuable fluorinated amino alcohol building block, offering unique reactivity due to the synergistic effects of its amine, hydroxyl, and difluoromethylene groups. This compound is essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where the introduction of fluorine atoms can dramatically alter biological activity, metabolic stability, and lipophilicity. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated drug candidates, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where fluorine incorporation enhances efficacy and environmental profile.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics and Bioisosteres: The difluoromethylene unit can act as a bioisostere for carbonyl or ether groups, useful in medicinal chemistry for improving peptide stability.
• Material Science: Incorporated into polymers and specialty coatings to impart unique surface properties and chemical resistance.
• Fluorine Chemistry Research: A versatile building block for academic and industrial research exploring new fluorination methodologies and fluorine-containing molecules.

Basic Information

Product Name	3-Amino-2,2-difluoropropan-1-ol
CAS No.	155310-11-5
Molecular Formula	C3H7F2NO
Molecular Weight	111.09 g/mol
Synonyms	2,2-Difluoro-3-aminopropan-1-ol; 3-Amino-2,2-difluoropropyl alcohol; 1-Propanol, 3-amino-2,2-difluoro-; 2,2-Difluoro-3-hydroxypropylamine; 3-Amino-1-hydroxy-2,2-difluoropropane; Amino-difluoropropanol; DFAP
EINECS	Contact for details

Quality Control

Every batch of 3-Amino-2,2-difluoropropan-1-ol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.