Description

3-Desmethyl Istradefylline is a key pharmaceutical intermediate and reference standard, specifically the desmethyl derivative of the adenosine A2A receptor antagonist Istradefylline. This compound is critical for analytical research, method development, and quality control in the synthesis of advanced neurological therapeutics. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) for the development and production of Parkinson's disease treatments.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for analytical method validation, HPLC, and LC-MS quantification in quality control laboratories.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a crucial synthetic precursor in the multi-step manufacturing process of Istradefylline and related adenosine receptor antagonists.
• Metabolite Studies: Employed in pharmacokinetic and drug metabolism research to study the metabolic pathways and bioavailability of Istradefylline.
• Biochemical Research: Used as a tool compound in neuroscience research to investigate the role of adenosine A2A receptors and their modulation.
• Impurity Standard: Essential for identifying and quantifying process-related impurities and degradants during API development and regulatory filing (e.g., ICH guidelines).
• Custom Synthesis Building Block: Provides a specialized chemical scaffold for medicinal chemistry programs aimed at developing new central nervous system (CNS) agents.

Basic Information

Product Name	3-Desmethyl Istradefylline
CAS No.	155272-04-1
Molecular Formula	C20H22N8O2
Molecular Weight	406.44 g/mol
Synonyms	8-[(E)-2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione; KW-6002 Desmethyl Impurity; Istradefylline Desmethyl Impurity; Istradefylline Related Compound; (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione; 1,3-Diethyl-8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-7-methyl-3,7-dihydro-1H-purine-2,6-dione
EINECS	Contact for details

Quality Control

Our 3-Desmethyl Istradefylline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and stringent control of residual solvents and related substances in compliance with ICH guidelines. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and consistency for your critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the material should be handled in a low-humidity environment and the container kept sealed after each use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.