Description

18,19-Dehydrobuprenorphine is a high-purity synthetic opioid derivative and a key chemical intermediate in advanced pharmaceutical research and development. This compound is critical for the study of opioid receptor pharmacology and the development of novel analgesic agents. It is primarily utilized by pharmaceutical R&D laboratories, analytical reference standard providers, and academic institutions engaged in neuropharmacology and medicinal chemistry.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control testing in laboratories.
• Medicinal Chemistry Research: Serves as a crucial intermediate or precursor in the synthesis and structure-activity relationship (SAR) studies of new opioid receptor ligands.
• Metabolite Studies: Employed in the identification and quantification of buprenorphine metabolites for forensic and clinical toxicology analysis.
• Biochemical Assay Development: Used in vitro to study binding affinity and functional activity at mu, kappa, and delta opioid receptors.
• Academic Research: A vital tool for universities and research institutes investigating pain pathways, addiction mechanisms, and opioid receptor biology.

Basic Information

Product Name	18,19-Dehydrobuprenorphine
CAS No.	155203-05-7
Molecular Formula	C29H41NO4
Molecular Weight	467.64 g/mol
Synonyms	21-Cyclopropyl-7α-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-etheno-6,7,8,14-tetrahydrooripavine; Buprenorphine Impurity F; Dehydrobuprenorphine; 6,14-ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α-methyl-, (5α,7α); UNII-7VJ28056I2
EINECS	Contact for details

Quality Control

Our 18,19-Dehydrobuprenorphine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods. We adhere to relevant ICH guidelines for the characterization of pharmaceutical impurities and reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the certificate of analysis. The material should be kept in a cool, dry, and well-ventilated area away from incompatible substances.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.