Description

3,3-Difluoropropanoic Acid is a versatile fluorinated carboxylic acid building block essential for advanced organic synthesis. Its unique structure, featuring two fluorine atoms on the β-carbon, makes it a critical intermediate for introducing difluoroalkyl motifs into target molecules. This compound is particularly valuable for researchers and manufacturers in the pharmaceutical and agrochemical sectors seeking to modulate the physicochemical properties and metabolic stability of new chemical entities. The high purity material is supplied to meet the stringent demands of modern R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring difluoroethyl or difluoromethyl ether groups to enhance bioavailability and metabolic resistance.
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and insecticides where the difluoro moiety can improve lipophilicity and target binding.
• Liquid Crystal & Electronic Materials: Serves as a precursor for fluorinated monomers and additives used in liquid crystal displays (LCDs) and dielectric materials.
• Peptide & Protein Modification: Employed to introduce fluorinated labels or stable isotopic labels (e.g., via activated esters) for biochemical research and proteomics.
• Organic Synthesis Reagent: A valuable reagent for preparing difluorinated analogs of natural products and for use in cross-coupling reactions and homologation sequences.
• Polymer & Material Science: Acts as a monomer or co-monomer for creating specialty fluoropolymers with unique surface properties and chemical resistance.

Basic Information

Product Name	3,3-Difluoropropanoic Acid
CAS No.	155142-69-1
Molecular Formula	C3H4F2O2
Molecular Weight	110.06 g/mol
Synonyms	3,3-Difluoropropionic Acid; 3,3-Difluoropropanoic Acid; 3,3-Difluoropropionic Acid; β,β-Difluoropropionic Acid; 3,3-Difluoropropansäure (German); Acide 3,3-difluoropropanoïque (French); 2,2-Difluoroethanecarboxylic Acid; DFPA
EINECS	Contact for details

Quality Control

Our 3,3-Difluoropropanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatographic purity analysis and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing specific results for purity, assay, and impurity profiles is provided with every shipment. We support compliance with global regulatory frameworks, including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its nature as a strong acid/organic solvent, it should be stored separately from strong bases, oxidizing agents, and reactive metals. Containers should be kept tightly sealed when not in use to maintain quality.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.