Description

6(R)-(4-Carboxyphenylthio)-5(S)-Hydroxy-7(E),9(E),11(Z),14(Z)-Eicosatetraenoic Acid is a high-purity, synthetic eicosanoid derivative of significant interest in advanced biochemical research and pharmaceutical development. This compound serves as a potent and selective inhibitor of key enzymes in the arachidonic acid cascade, making it a critical tool for modulating inflammatory and thrombotic pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of novel therapeutics for cardiovascular, inflammatory, and autoimmune diseases.

Application

• Biochemical Research: Used as a reference standard and a potent, selective inhibitor in studies of lipoxygenase (LOX) and cyclooxygenase (COX) enzyme pathways.
• Pharmaceutical R&D: A key intermediate or pharmacophore in the discovery and development of novel anti-inflammatory, anti-thrombotic, and cardioprotective drug candidates.
• Cell Signaling Studies: Employed to investigate the role of specific eicosanoid metabolites in cellular processes, including inflammation, apoptosis, and immune response.
• Enzyme Kinetics: Acts as a substrate analog or inhibitor to study enzyme mechanism, kinetics, and inhibition profiles in vitro.
• Metabolite Standard: Serves as a high-purity analytical standard for the quantification of related eicosanoid metabolites in biological samples via LC-MS or HPLC.

Basic Information

Product Name	6(R)-(4-Carboxyphenylthio)-5(S)-Hydroxy-7(E),9(E),11(Z),14(Z)-Eicosatetraenoic Acid
CAS No.	154978-38-8
Molecular Formula	C27H36O5S
Molecular Weight	472.64 g/mol
Synonyms	5(S)-Hydroxy-6(R)-(4-carboxyphenylthio)-7(E),9(E),11(Z),14(Z)-eicosatetraenoic acid; 6(R)-(4-Carboxyphenylthio)-5(S)-HETE; SKF 104353 carboxylic acid; LTB4 antagonist analog; 5-Hydroxy-6-(4-carboxyphenylthio)-7,9,11,14-eicosatetraenoic acid; 6-(4-Carboxyphenylthio)-5-hydroxy-7,9,11,14-eicosatetraenoic acid
EINECS	Contact for details

Quality Control

Our 6(R)-(4-Carboxyphenylthio)-5(S)-Hydroxy-7(E),9(E),11(Z),14(Z)-Eicosatetraenoic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to verify stereochemical integrity. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 98.0% ee (by chiral HPLC)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.