Description

4-Acetamidophenyl-Ring-Ul-14C Glucuronide is a high-purity, carbon-14 labeled metabolite reference standard, essential for advanced analytical research and development. Its primary value lies in enabling precise metabolic pathway tracing and quantitative analysis in pharmacokinetic and ADME (Absorption, Distribution, Metabolism, and Excretion) studies. This compound is critically needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on drug metabolism and safety evaluation.

Application

• Metabolite Identification and Profiling: Serves as a critical reference standard for identifying and quantifying glucuronide metabolites of acetaminophen (paracetamol) in biological matrices.
• ADME/Tox Studies: Used in radiolabeled studies to track the absorption, distribution, metabolism, and excretion of parent compounds, providing vital data for drug candidate development.
• Mass Spectrometry Calibration: Acts as an internal standard for Liquid Chromatography-Mass Spectrometry (LC-MS) and LC-MS/MS methods, ensuring analytical accuracy and reproducibility.
• Enzyme Kinetic Studies: Employed in research on UDP-glucuronosyltransferase (UGT) enzyme activity and kinetics to understand metabolic conjugation pathways.
• Drug-Drug Interaction Research: Utilized to investigate potential interactions that affect glucuronidation pathways, a key factor in drug safety assessments.
• Regulatory Submission Support: Provides definitive metabolite characterization data required for regulatory filings with agencies like the FDA and EMA.

Basic Information

Product Name	4-Acetamidophenyl-Ring-Ul-14C Glucuronide
CAS No.	154804-55-4
Molecular Formula	C₁₅H₁₇¹⁴CNO₈
Molecular Weight	Contact for details
Synonyms	Paracetamol Glucuronide (Ring-Ul-14C); APAP-Glucuronide (14C-labeled); N-Acetyl-p-aminophenyl-β-D-glucopyranosiduronic Acid (Ring-Ul-14C); 4'-Hydroxyacetanilide Glucuronide (14C); Acetaminophen β-D-Glucuronide (Ring-Ul-14C); 1-O-(4-Acetamidophenyl)-β-D-Glucopyranuronic Acid (Ring-Ul-14C); (4-Acetamidophenyl)-β-D-Glucopyranosiduronic Acid (Ring-Ul-14C)
EINECS	Contact for details

Quality Control

Every batch of 4-Acetamidophenyl-Ring-Ul-14C Glucuronide is manufactured and analyzed under strict quality systems to ensure the highest standards of radiochemical purity, chemical purity, and specific activity. Our quality control protocols are designed to meet the rigorous demands of pharmaceutical R&D and regulatory compliance. Comprehensive Certificates of Analysis (COA) are provided, detailing results from advanced analytical techniques including HPLC, LC-MS, and NMR for structural confirmation and purity verification.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Handle and store in accordance with all applicable radiation safety regulations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Radiochemical Purity (HPLC)	≥ 98%
Chemical Purity (HPLC)	≥ 95%
Specific Activity	Contact for details (mCi/mmol)
Solubility	Soluble in water, methanol, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.