Description

Hyaluronan-Binding Protein, Brain Enriched is a specialized protein that selectively binds to hyaluronan, a key component of the extracellular matrix. This specific interaction is crucial for research into neural development, brain tumor biology, and the molecular mechanisms of neurodegenerative diseases. It is an essential reagent for neuroscientists, molecular biologists, and pharmaceutical researchers focused on central nervous system disorders and glycan biology.

Application

• Neuroscience Research: Used as a probe to study hyaluronan distribution and function in brain tissue sections and cell cultures.
• Cancer Biology: Investigation of glioblastoma and other brain tumors where hyaluronan and its binding partners play a critical role in tumor progression and metastasis.
• Biochemical Assay Development: Serves as a critical component in ELISA, blotting, and other assays designed to detect, quantify, or purify hyaluronan.
• Drug Discovery Screening: Target protein for high-throughput screening of compounds aimed at modulating hyaluronan-protein interactions for therapeutic benefit.
• Extracellular Matrix (ECM) Studies: Tool for elucidating the structure and function of the neural ECM and its role in synaptic plasticity and neural repair.
• Diagnostic Reagent Development: Potential use in developing diagnostic tools for conditions characterized by altered hyaluronan metabolism in the CNS.

Basic Information

Product Name	Hyaluronan-Binding Protein, Brain Enriched
CAS No.	154769-09-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Brain Enriched Hyaluronan Binding Protein (BEHAB); Brevican; Hyaluronan-binding proteoglycan brevican; Aggrecan family member; CSPG7; BEHAB/brevican; PG-350; Chondroitin sulfate proteoglycan 7; Brain-specific chondroitin sulfate proteoglycan
EINECS	Contact for details

Quality Control

Our Hyaluronan-Binding Protein, Brain Enriched is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes rigorous quality testing, including purity analysis by SDS-PAGE and HPLC, functional activity assays (e.g., hyaluronan binding ELISA), and confirmation of identity. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Single major band corresponding to expected molecular weight
Purity (HPLC)	≥ 90%
Protein Content (BCA)	≥ 95% of total mass
Endotoxin Level (LAL)	< 1.0 EU/µg
Biological Activity (Binding Assay)	Confirmed specific binding to hyaluronan
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.