Description

2-Chloro-4-[3-(Trifluoromethyl)Phenyl]Benzonitrile is a high-value, multi-functional aromatic nitrile building block characterized by its chloro and trifluoromethylphenyl substituents. This compound matters for its role as a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its unique structure imparts desirable properties to the final products. It is primarily needed by research and development chemists, process scale-up teams, and manufacturers in the agrochemical, pharmaceutical, and specialty chemical industries seeking to develop novel compounds with enhanced performance.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of novel drug candidates, particularly in areas targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Serves as a versatile precursor for developing new-generation herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Liquid Crystal & OLED Material Development: Used in the synthesis of advanced organic electronic materials for displays and lighting due to its stable aromatic core and halogenated motifs.
• Polymer & Resin Modifier: Incorporated as a monomer or additive to enhance thermal stability, chemical resistance, and specific functional properties in high-performance polymers.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and cyano-group transformations for constructing complex molecular architectures in academic and industrial R&D.

Basic Information

Product Name	2-Chloro-4-[3-(Trifluoromethyl)Phenyl]Benzonitrile
CAS No.	154606-29-8
Molecular Formula	C14H7ClF3N
Molecular Weight	281.66 g/mol
Synonyms	2-Chloro-4-[3-(trifluoromethyl)phenyl]benzonitrile; 2-Chloro-4'-(trifluoromethyl)[1,1'-biphenyl]-4-carbonitrile; 4-(3-Trifluoromethylphenyl)-2-chlorobenzonitrile; [1,1'-Biphenyl]-4-carbonitrile, 2-chloro-4'-(trifluoromethyl)-; 2-Chloro-4-(3-trifluoromethylphenyl)benzonitrile; 2-Chloro-4-(α,α,α-trifluoro-m-tolyl)benzonitrile
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-[3-(Trifluoromethyl)Phenyl]Benzonitrile is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container must be kept tightly closed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.