Description

Stauprimide CAS NO 154589-96-5 is a potent and selective small molecule inhibitor of the c-Myc transcription factor, functioning by disrupting the N-Myc/Max dimerization essential for oncogenic activity. This compound is a critical research tool for studying the role of Myc proteins in cell proliferation, differentiation, and apoptosis, particularly in cancer biology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, neurobiology, and stem cell research to elucidate disease mechanisms and identify novel therapeutic targets.

Application

• Oncology Research: Investigation of c-Myc and N-Myc oncogene function in various cancer cell lines and tumor models.
• Stem Cell Differentiation Studies: Used to modulate Myc activity to control embryonic stem (ES) cell self-renewal and direct differentiation.
• Neurobiology Research: Exploration of N-Myc's role in neural development and neuroblastoma pathogenesis.
• Mechanistic Biochemistry: A key reagent for studying protein-protein interactions, specifically the Myc/Max dimerization complex.
• High-Throughput Screening (HTS): Serves as a reference compound or positive control in assays designed to discover new Myc pathway inhibitors.
• Preclinical Drug Discovery: Validation of the Myc pathway as a therapeutic target in proof-of-concept studies.

Basic Information

Product Name	Stauprimide
CAS No.	154589-96-5
Molecular Formula	C₂₈H₂₈N₄O₄
Molecular Weight	484.55 g/mol
Synonyms	NSC 14613; 2-[(2E)-3-(2,3-Dimethoxyphenyl)-2-propenoyl]-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester; Myc Inhibitor II; Stauprimide (Myc inhibitor); (E)-Methyl 2-(3-(2,3-dimethoxyphenyl)acryloyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
EINECS	Contact for details

Quality Control

Our Stauprimide is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity confirmation and identity verification via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.