Description

Fmoc-L-Asn(β-D-Glc(Ac)4-OH) is a sophisticated, orthogonally protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound matters because it provides a critical building block for the synthesis of complex glycopeptides, enabling precise research into protein glycosylation and its biological roles. Pharmaceutical R&D laboratories and biotechnology companies focused on developing novel therapeutics, diagnostics, and research tools for cancer, immunology, and metabolic diseases are the primary users of this high-value intermediate.

Application

• Glycopeptide Synthesis: A key protected intermediate for the automated solid-phase synthesis of O-linked glycopeptides, particularly those containing N-acetylglucosamine (GlcNAc) moieties.
• Pharmaceutical Research: Used in the development of novel glycoprotein-based therapeutics, including monoclonal antibodies, vaccines, and enzyme replacement therapies where specific glycosylation patterns are crucial for activity.
• Chemical Biology Probes: Enables the creation of site-specifically glycosylated peptides for studying carbohydrate-protein interactions, signal transduction, and intracellular trafficking.
• Bioconjugation: Serves as a specialized precursor for creating peptide-based conjugates used in targeted drug delivery systems and diagnostic imaging agents.
• Academic Research: Fundamental tool in university and institutional labs for investigating the structural and functional impact of glycosylation on peptide and protein folding, stability, and receptor binding.

Basic Information

Product Name	Fmoc-L-Asn(β-D-Glc(Ac)4-OH)
CAS No.	154395-64-9
Molecular Formula	C₃₅H₄₂N₂O₁₅
Molecular Weight	754.72 g/mol
Synonyms	Fmoc-Asn(GlcNAc(Ac)₃)-OH; Nα-Fmoc-Nβ-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl)-L-asparagine; Fmoc-L-asparagine, N-[2-(acetylamino-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl)]-, 9-fluorenylmethyl ester; Fmoc-Asn(Ac₃-β-D-GlcNAc)-OH; Fmoc-Asn(β-D-GlcNAc(Ac)₃)-OH; Fmoc-Asn(GlcNAc(Acetyl)₃)-OH; Glycopeptide Building Block 154395-64-9
EINECS	Contact for details

Quality Control

Every batch of Fmoc-L-Asn(β-D-Glc(Ac)4-OH) is produced and handled under strict quality management protocols. We employ advanced analytical techniques, including HPLC, NMR, and MS, to ensure identity, purity, and chiral integrity. Our production adheres to cGMP principles where applicable, guaranteeing consistency and traceability for critical research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and solvent residues is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry atmosphere before opening to prevent condensation and hydrolysis. For long-term stability, store under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 99.0% (L-Isomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.