Description

n-1-(2-Nitrophenyl)Ethoxycarbonylserine is a specialized, high-purity amino acid derivative featuring a photolabile protecting group. This compound is critical for advanced peptide synthesis and biochemical research, where precise, light-triggered deprotection is required. It is primarily utilized by pharmaceutical R&D teams, peptide manufacturers, and academic research institutions developing novel therapeutic agents and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the controlled, sequential introduction of serine residues using photoremovable protecting groups.
• Photolithographic Peptide Array Fabrication: Enables the light-directed, spatially addressable synthesis of high-density peptide microarrays for drug discovery and diagnostic applications.
• Bioconjugation and Linker Chemistry: Serves as a versatile linker or spacer molecule for attaching peptides or proteins to surfaces, nanoparticles, or other biomolecules with light-sensitive cleavage.
• Proteomics and Biochemical Research: Used in the study of protein-protein interactions, enzyme kinetics, and the development of activity-based probes where temporal control is essential.
• Precursor for Advanced Intermediates: Acts as a starting material or intermediate in the synthesis of more complex, photolabile compounds for targeted drug delivery systems.

Basic Information

Product Name	n-1-(2-Nitrophenyl)Ethoxycarbonylserine
CAS No.	154187-38-9
Molecular Formula	C12H14N2O7
Molecular Weight	298.25 g/mol
Synonyms	N-1-(2-Nitrophenyl)ethoxycarbonyl-L-serine; NPEOC-Ser-OH; 2-Nitrophenylethyloxycarbonylserine; (S)-2-(((2-Nitrophenyl)ethoxy)carbonylamino)-3-hydroxypropanoic acid; N-[(2-Nitrophenyl)ethoxycarbonyl]serine; NPEOC-Ser; Photolabile Serine Derivative; N-(1-(2-Nitrophenyl)ethoxycarbonyl)serine
EINECS	Contact for details

Quality Control

Our n-1-(2-Nitrophenyl)Ethoxycarbonylserine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research or cGMP-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the container should be kept in a desiccated environment. Allow the sealed container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.