Description

n-Deethyl Dorzolamide is a key pharmaceutical intermediate and reference standard, primarily known for its role in the synthesis and analytical profiling of carbonic anhydrase inhibitors. This compound is of critical importance for ensuring the quality, safety, and efficacy of related active pharmaceutical ingredients (APIs) and finished drug products. It is essential for pharmaceutical R&D laboratories, quality control departments, and manufacturers involved in producing ophthalmic medications and other therapeutic agents targeting carbonic anhydrase.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of advanced carbonic anhydrase inhibitors and related drug candidates.
• Analytical Reference Standard: Used for method development, validation, and routine quality control (QC) testing in HPLC, LC-MS, and other chromatographic systems to ensure API purity and identity.
• Impurity Standard: Serves as a certified reference material for identifying, quantifying, and monitoring process-related impurities and degradation products in Dorzolamide and its derivatives.
• Research & Development: Employed in biochemical and pharmacological studies to investigate structure-activity relationships (SAR) and the mechanism of action of enzyme inhibitors.
• Metabolite Studies: Utilized in pharmacokinetic and metabolic pathway research to understand the biotransformation of parent drug compounds.

Basic Information

Product Name	n-Deethyl Dorzolamide
CAS No.	154154-90-2
Molecular Formula	C8H12N2O5S3
Molecular Weight	312.39 g/mol
Synonyms	(4S,6S)-4-(Aminomethyl)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide; L-671,152; Dorzolamide Desethyl Impurity; Dorzolamide N-Deethyl; Dorzolamide EP Impurity C; Dorzolamide Related Compound C; 5,6-Dihydro-4H-4-(aminomethyl)thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
EINECS	Contact for details

Quality Control

Our n-Deethyl Dorzolamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by IR and NMR, purity assay by HPLC, and control of specified impurities, to ensure it meets high-purity standards suitable for pharmaceutical R&D and analytical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.