Description

4-Bromo-2-Iodophenyl Trifluoromethyl Ether, also known as 4-Bromo-2-Iodo-Alpha,Alpha,α-Trifluoroanisole, is a high-value, multi-halogenated aromatic ether building block of significant interest in advanced organic synthesis. Its unique structure, featuring both bromine and iodine substituents alongside a trifluoromethoxy group, makes it a versatile and reactive intermediate for constructing complex molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology, where the trifluoromethoxy group can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the halogen atoms for further functionalization to tune biological activity.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands for transition metal catalysis, including cross-coupling reactions like Suzuki-Miyaura and Buchwald-Hartwig amination.
• Material Science Research: Employed in the creation of organic electronic materials, such as semiconductors for OLEDs or OFETs, where the halogenated aromatic core contributes to charge transport properties.
• Fluorine Chemistry Building Block: The presence of the trifluoromethoxy group makes it a valuable synthon for introducing fluorine motifs into target molecules, a common strategy in modern medicinal and materials chemistry.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CDMOs for client-directed synthesis projects requiring precise, high-purity halogenated intermediates.

Basic Information

Product Name	4-Bromo-2-Iodophenyl Trifluoromethyl Ether, 4-Bromo-2-Iodo-Alpha,Alpha,α-Trifluoroanisole
CAS No.	154065-33-5
Molecular Formula	C7H3BrF3IO
Molecular Weight	366.90 g/mol
Synonyms	1-Bromo-4-(trifluoromethoxy)-2-iodobenzene; 4-Bromo-2-iodo-1-(trifluoromethoxy)benzene; 2-Iodo-4-bromophenyl trifluoromethyl ether; 4-Bromo-2-iodo-α,α,α-trifluoroanisole; Benzene, 1-bromo-4-(trifluoromethoxy)-2-iodo-; 4-Bromo-2-iodo-1-trifluoromethoxybenzene; 4-Bromo-2-iodophenyl trifluoromethylether
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-2-Iodophenyl Trifluoromethyl Ether is produced and analyzed under strict quality management protocols. Our products undergo rigorous purity and identity testing, including HPLC, GC, NMR, and mass spectrometry, to ensure they meet the exacting standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Assay	≥95.0%
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.