Description

Boc-(o-Benzyl)-Tyrosine Nca is a specialized N-carboxyanhydride (NCA) derivative of the amino acid tyrosine, protected at both the amine and phenolic hydroxyl groups. This compound is a critical building block in the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics, enabling precise control over polymer sequence and architecture. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, biomaterials, and advanced drug delivery systems. Its high reactivity and defined stereochemistry make it indispensable for producing peptides with specific biological activities.

Application

• Peptide Synthesis: Serves as a key monomer for the ring-opening polymerization (ROP) to prepare well-defined polypeptides and poly(amino acid)s.
• Pharmaceutical Research: Used in the research and development of peptide-based drugs, including hormone analogs, antimicrobial peptides, and targeted therapeutics.
• Biomaterial Fabrication: Enables the synthesis of biodegradable and biocompatible polymers for tissue engineering scaffolds and medical implants.
• Drug Delivery Systems: A precursor for creating smart polymer carriers that respond to specific biological stimuli for controlled drug release.
• Chemical Biology: Employed in the synthesis of peptide probes and tools for studying protein-protein interactions and enzyme mechanisms.
• Specialty Polymers: Used to create advanced materials with specific chiral, mechanical, or self-assembly properties.

Basic Information

Product Name	Boc-(o-Benzyl)-Tyrosine Nca
CAS No.	153815-62-4
Molecular Formula	C22H23NO6
Molecular Weight	397.42 g/mol
Synonyms	Nα-Boc-O-benzyl-L-tyrosine N-carboxyanhydride; Boc-Tyr(Bzl)-NCA; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(benzyloxy)phenyl)propanoic acid N-carboxyanhydride; tert-Butyloxycarbonyl-O-benzyltyrosine NCA; Fmoc-Tyr(Bzl)-OH NCA (common misnomer); BOC-L-Tyrosine(O-Benzyl)-NCA; NCA of Boc-Tyr(Bzl)-OH; 5-Oxazolidinedione, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-3-[4-(phenylmethoxy)phenyl]-, (4S)-
EINECS	Contact for details

Quality Control

Our Boc-(o-Benzyl)-Tyrosine Nca is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and FT-IR for functional group verification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports applications in cGMP and GLP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (e.g., argon or nitrogen) due to its moisture-sensitive and light-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.