Description

1-(14-Hydroxy-3,6,9,12-Tetraoxatetradecyl)-1H-Pyrrole-2,5-Dione is a specialized bifunctional chemical intermediate featuring a hydrophilic tetraethylene glycol spacer linked to a reactive maleimide moiety. This compound matters for its unique ability to act as a heterobifunctional crosslinker, enabling the precise conjugation of biomolecules and polymers under mild, aqueous conditions. It is primarily needed by researchers and manufacturers in the bioconjugation, pharmaceutical development, and advanced materials sectors for creating targeted drug delivery systems, diagnostic reagents, and functionalized hydrogels.

Application

• Bioconjugation and Protein Modification: Used to attach peptides, proteins, or antibodies to other molecules (e.g., polymers, surfaces, drugs) via thiol-maleimide chemistry.
• PEGylation Reagent: Serves as an activated PEG derivative for modifying therapeutic proteins to enhance solubility, stability, and circulation half-life.
• Polymer Functionalization: A key monomer or end-capping agent for synthesizing stimuli-responsive or bioactive polymers and hydrogels.
• Surface Immobilization: Facilitates the covalent attachment of biomolecules to sensor chips, nanoparticles, or chromatographic supports for biosensing and diagnostics.
• Linker for Antibody-Drug Conjugates (ADCs): Employed in the design and synthesis of cleavable or non-cleavable linkers for targeted cancer therapies.
• Nanoparticle Functionalization: Used to coat nanoparticles with a hydrophilic, biocompatible PEG shell while providing reactive sites for further coupling.

Basic Information

Product Name	1-(14-Hydroxy-3,6,9,12-Tetraoxatetradecyl)-1H-Pyrrole-2,5-Dione
CAS No.	153758-87-3
Molecular Formula	C16H25NO8
Molecular Weight	359.37 g/mol
Synonyms	Maleimide-PEG4-alcohol; 1-[2-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethyl]-1H-pyrrole-2,5-dione; 4-Maleimidobutyric Acid PEG4 Ester; α-Maleimido-ω-hydroxy-tetraethylene glycol; N-(3-Hydroxypropyl)maleimide PEG4; PEG4 Maleimide Alcohol; 1-(14-Hydroxy-3,6,9,12-tetraoxatetradecyl)-2,5-pyrroledione; MAL-PEG4-OH
EINECS	Contact for details

Quality Control

Our 1-(14-Hydroxy-3,6,9,12-Tetraoxatetradecyl)-1H-Pyrrole-2,5-Dione is manufactured under strict quality protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with high-purity research and cGMP-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic and moisture-sensitive nature, the container should be sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to prevent degradation. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meet ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.