Description

Neutrophil Inhibitory Factor CAS NO 153591-89-0 is a synthetic peptide designed to modulate the activity of neutrophils, a key component of the innate immune system. This compound is of significant interest for its potential to intervene in inflammatory pathways where excessive neutrophil activation contributes to tissue damage. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for drug discovery, preclinical studies, and the development of novel anti-inflammatory therapeutics.

Application

• Pharmaceutical Research: A critical tool for investigating the role of neutrophils in inflammatory diseases such as acute respiratory distress syndrome (ARDS), sepsis, and rheumatoid arthritis.
• Drug Discovery & Development: Serves as a reference standard or active pharmaceutical ingredient (API) in the development of new anti-inflammatory and immunomodulatory drugs.
• Biochemical Assays: Used in in vitro and cell-based assays to study neutrophil adhesion, migration, and activation mechanisms.
• Preclinical Studies: Employed in animal models to evaluate the efficacy and safety of potential therapeutic candidates targeting neutrophil-mediated inflammation.
• Academic Research: Supports fundamental research in immunology and inflammation biology at universities and research institutes.

Basic Information

Product Name	Neutrophil Inhibitory Factor
CAS No.	153591-89-0
Molecular Formula	C186H317N55O58S2
Molecular Weight	4193.1 g/mol
Synonyms	NIF; Neutrophil Inhibitory Factor (1-37), human; Recombinant Human Neutrophil Inhibitory Factor; rHuNIF; sLe(x)-Glycoprotein Ligand-1; sLe(x)-GPL-1; CD62L ligand; L-Selectin ligand; TYR-GLU-PRO-LEU-TYR-LEU-ASP-GLN-ALA-LYS-VAL-ALA-PHE-VAL-SER-PRO-GLU-ARG-PRO-GLY-PRO-PRO-GLN-GLY-PRO-PRO-GLN-GLY-PRO-PRO-GLN-GLY-PRO-PRO-GLN-GLY-PRO-PRO-GLN
EINECS	Contact for details

Quality Control

Our Neutrophil Inhibitory Factor is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and endotoxin testing. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize moisture absorption. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%
Endotoxin	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.