Description

2,4-Difluorophenyl Chlorothioformate is a specialized organosulfur reagent featuring a reactive chlorothioformate group on a difluorinated aromatic ring. This compound matters as a versatile building block for introducing the 2,4-difluorophenylthio moiety into target molecules, enabling the synthesis of complex chemical architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and crop protection agent development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of novel small molecule drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the difluorophenyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced materials.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and organocatalysts.
• Chemical Biology Probes: Useful for the selective modification of proteins, peptides, and other biomolecules in research settings.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2,4-Difluorophenyl Chlorothioformate
CAS No.	153585-18-3
Molecular Formula	C7H3ClF2OS
Molecular Weight	208.61 g/mol
Synonyms	Carbonochloridothioic acid, O-(2,4-difluorophenyl) ester; Chlorothioformic acid O-(2,4-difluorophenyl) ester; 2,4-Difluorophenyl chloromethanethioate; 2,4-Difluorophenyl thiochloroformate; O-(2,4-Difluorophenyl) chlorothioformate; (2,4-Difluorophenoxy)(chloro)methanethione
EINECS	Contact for details

Quality Control

Our 2,4-Difluorophenyl Chlorothioformate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, oxidizing agents, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.