Description

n-(1-Pyrenemethyl)Iodoacetamide is a specialized, high-purity biochemical reagent designed for advanced labeling and crosslinking applications. This compound matters for researchers and manufacturers requiring a precise, fluorescent probe with a reactive iodoacetyl group for thiol-specific conjugation under mild conditions. It is primarily needed by professionals in bioconjugation, proteomics, and materials science for developing sensitive detection assays, functionalizing surfaces, and synthesizing novel polymer architectures.

Application

• Fluorescent Labeling of Biomolecules: Used as a thiol-reactive probe for site-specific labeling of proteins, peptides, and antibodies with a pyrene fluorophore for fluorescence spectroscopy and microscopy studies.
• Bioconjugation and Crosslinking: Serves as a key reagent for creating stable thioether linkages, enabling the construction of protein-drug conjugates, antibody-oligonucleotide hybrids, and other complex biomolecular assemblies.
• Polymer and Materials Functionalization: Employed to introduce pyrene chromophores into polymer chains or onto material surfaces (e.g., nanoparticles, beads) for photophysical studies, sensing applications, or to modify surface properties.
• Proteomics Research: Utilized in activity-based protein profiling (ABPP) and other chemical proteomics strategies to tag and identify cysteine-containing enzymes and proteins.
• Development of Diagnostic Assays: Acts as a critical component in the synthesis of fluorescent probes and sensors for detecting specific analytes or enzymatic activities in diagnostic kits.
• Organic Synthesis Intermediate: Functions as a building block for synthesizing more complex pyrene-derived compounds for organic electronic materials or advanced research chemicals.

Basic Information

Product Name	n-(1-Pyrenemethyl)Iodoacetamide
CAS No.	153534-76-0
Molecular Formula	C19H14INO
Molecular Weight	423.23 g/mol
Synonyms	1-Pyrenemethyl iodoacetamide; N-[(1-Pyrenyl)methyl]-2-iodoacetamide; 2-Iodo-N-(pyren-1-ylmethyl)acetamide; Iodoacetamide pyrene derivative; Pyrene iodoacetamide; Thiol-reactive pyrene probe; N-(1-Pyrenylmethyl)iodoacetamide; Pyrene-methyl-iodoacetamide
EINECS	Contact for details

Quality Control

Every batch of n-(1-Pyrenemethyl)Iodoacetamide is manufactured under strict quality protocols and undergoes comprehensive analytical testing to ensure identity, purity, and performance consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality management system adheres to ISO 9001 standards, guaranteeing traceability and reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions, moisture, or light may lead to decomposition or reduced reactivity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown powder or crystals
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 1.0 %
Heavy Metals	≤ 20 ppm
Solubility Test	Clear, yellow solution in DMSO or DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.