Description

Folic Acid NHS Ester is a highly reactive, amine-reactive derivative of folic acid, designed for efficient bioconjugation. This compound is critical for creating stable covalent bonds between folic acid and biomolecules like proteins, peptides, or antibodies. It is primarily utilized by researchers and manufacturers in the pharmaceutical, diagnostic, and life science industries for targeted drug delivery systems, immunoassays, and the development of novel therapeutic conjugates.

Application

• Bioconjugation Reagent: For the covalent attachment of folic acid to antibodies, proteins, or nanoparticles to create targeted delivery vehicles.
• Pharmaceutical Research: A key intermediate in the development of folate-receptor targeting prodrugs and antibody-drug conjugates (ADCs) for cancer therapy.
• Diagnostic Probe Synthesis: Used to label folic acid with fluorescent dyes, enzymes, or other reporter molecules for in vitro and in vivo imaging and detection.
• Biomaterial Functionalization: Surface modification of polymers, dendrimers, or liposomes to enhance their targeting specificity to folate receptor-positive cells.
• Life Science Research: Tool compound for studying folate receptor biology, cellular uptake mechanisms, and drug delivery pathways.
• Immunoassay Development: Conjugation agent for preparing enzyme- or tag-linked folic acid used in competitive binding assays.

Basic Information

Product Name	Folic Acid NHS Ester
CAS No.	153445-05-7
Molecular Formula	C26H27N9O8
Molecular Weight	593.55 g/mol
Synonyms	Folic Acid N-Hydroxysuccinimide Ester; N-Hydroxysuccinimide Folic Acid Ester; Folate NHS Ester; PGA-NHS; Pteroylglutamic Acid N-Succinimidyl Ester; Vitamin B9 NHS Ester; N-(p-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic Acid 1-(2,5-Dioxopyrrolidin-1-yl) Ester
EINECS	Contact for details

Quality Control

Our Folic Acid NHS Ester is manufactured under strict quality protocols. Each batch is characterized and tested to ensure high purity and consistent reactivity, suitable for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC is provided with every shipment to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.