Description

Threo-Dihydrobupropion is a key pharmaceutical intermediate and metabolite of the antidepressant bupropion. This compound matters for its critical role in the synthesis and analytical profiling of active pharmaceutical ingredients (APIs) within the central nervous system therapeutic class. It is primarily needed by pharmaceutical R&D laboratories, analytical service providers, and manufacturers engaged in the production of generic or novel bupropion-based formulations.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of bupropion hydrochloride and related analogs.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control testing in pharmaceutical manufacturing.
• Metabolite Studies: Employed in pharmacokinetic and pharmacodynamic research to study the metabolism, efficacy, and safety profile of bupropion.
• Impurity Profiling: Serves as an impurity marker or standard to monitor and control the quality of bupropion API batches according to ICH guidelines.
• Clinical Research: Utilized in bioanalytical assays for quantifying metabolite levels in biological samples during clinical trials.
• Academic Research: A valuable compound for neuroscience and medicinal chemistry research exploring the structure-activity relationships of aminoketone antidepressants.

Basic Information

Product Name	Threo-Dihydrobupropion
CAS No.	153365-82-3
Molecular Formula	C13H19ClNO
Molecular Weight	240.75 g/mol
Synonyms	(2R,3R)-2-(tert-Butylamino)-3-chloropropiophenone; (2R,3R)-2-[(1,1-Dimethylethyl)amino]-3'-chloropropiophenone; (2R,3R)-2-(tert-Butylamino)-3'-chloropropiophenone; (1R,2R)-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-one; Threo-dihydrobupropion; Bupropion metabolite; BW 306U; AH 5152
EINECS	Contact for details

Quality Control

Our Threo-Dihydrobupropion is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for isomeric content, and comprehensive identification tests to ensure compliance with pharmaceutical-grade standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (Threo isomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.