Description

2,2'-Bis(Di-p-Tolylphosphino)-1,1'-Binaphthyl CAS NO 153305-67-0 is a chiral, bidentate phosphine ligand widely used in asymmetric catalysis. This compound is highly valued for its ability to induce high enantioselectivity in a variety of transition metal-catalyzed reactions, enabling the production of optically active intermediates. It is an essential tool for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control in their synthetic processes.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for the synthesis of enantiomerically pure amino acids, alcohols, and other chiral building blocks.
• Catalyst component for asymmetric cross-coupling reactions, including Suzuki-Miyaura and Negishi couplings, to form chiral biaryl compounds.
• Employed in asymmetric allylic substitution reactions to create carbon-carbon and carbon-heteroatom bonds with high enantiomeric excess.
• Key reagent in the synthesis of chiral pharmaceuticals and active pharmaceutical ingredients (APIs) where specific stereochemistry is critical for biological activity.
• Used in the development of novel agrochemicals and flavors/fragrances that require enantioselective synthesis pathways.
• Fundamental research tool in academic and industrial R&D for exploring new catalytic methodologies and reaction mechanisms.

Basic Information

Product Name	2,2'-Bis(Di-p-Tolylphosphino)-1,1'-Binaphthyl
CAS No.	153305-67-0
Molecular Formula	C48H40P2
Molecular Weight	678.78 g/mol
Synonyms	DTB-BINAP; (R)-DTB-BINAP; (S)-DTB-BINAP; 2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl; (R)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl; (S)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl; (R)-DTB-BINAP Ligand; (S)-DTB-BINAP Ligand; 4,4',5,5'-Tetramethyl-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (common misnomer)
EINECS	Contact for details

Quality Control

Our 2,2'-Bis(Di-p-Tolylphosphino)-1,1'-Binaphthyl is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for sensitive catalytic applications. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, this material should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	Off-white to pale yellow powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (HPLC)	≥ 99.0% (for specified enantiomer)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.