Description

2,4-Bis(Trifluoromethyl)Phenylboronic Acid is a specialized organoboron compound featuring a phenyl ring substituted with two trifluoromethyl groups, making it a valuable building block in modern synthetic chemistry. This boronic acid derivative is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for forming carbon-carbon bonds under mild conditions. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating complex, fluorinated aromatic structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic moieties to enhance metabolic stability, bioavailability, and lipophilicity.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the introduction of the 2,4-bis(trifluoromethyl)phenyl group can improve product efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), where fluorine atoms help tune electronic properties and stability.
• Polymer & Resin Modification: Incorporated into specialty polymers to impart unique properties such as chemical resistance, thermal stability, and specific optical characteristics.
• Catalyst & Ligand Development: Utilized in the preparation of novel ligands and catalysts for asymmetric synthesis and other transition metal-catalyzed processes.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic routes and creating compound libraries for screening.

Basic Information

Product Name	2,4-Bis(Trifluoromethyl)Phenylboronic Acid
CAS No.	153254-09-2
Molecular Formula	C8H5BF6O2
Molecular Weight	257.93 g/mol
Synonyms	[2,4-Bis(trifluoromethyl)phenyl]boronic acid; 2,4-Bis(trifluoromethyl)benzeneboronic acid; (2,4-Bis(trifluoromethyl)phenyl)boronic acid; B-[2,4-Bis(trifluoromethyl)phenyl]boronic acid; 2,4-Di(trifluoromethyl)phenylboronic acid; 2,4-Bis(trifluoromethyl)phenyl-B(OH)2; 153254-09-2; Boronic acid, B-[2,4-bis(trifluoromethyl)phenyl]-
EINECS	Contact for details

Quality Control

Our 2,4-Bis(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory compliance needs in cGMP and ISO environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.