Description

Amyloid β-Protein(16-22) CAS NO 153247-41-7 is a synthetic peptide fragment corresponding to residues 16-22 of the amyloid beta (Aβ) protein, a key component implicated in the pathology of Alzheimer's disease. This high-purity peptide is essential for fundamental research into protein aggregation mechanisms, fibril formation, and neurotoxicity. It serves as a critical tool for biochemists, neuroscientists, and pharmaceutical researchers developing therapeutic strategies and diagnostic assays targeting amyloid-related disorders.

Application

• Biomedical Research: Core substrate for studying the kinetics and thermodynamics of amyloid beta aggregation and fibrillogenesis in vitro.
• Drug Discovery Screening: Used in high-throughput assays to identify and evaluate potential inhibitors of Aβ aggregation for Alzheimer's disease therapeutics.
• Biophysical Studies: Employed in techniques like NMR, FTIR, and electron microscopy to elucidate the secondary structure and morphology of amyloid peptides.
• Toxicity & Mechanism Studies: Investigation of the structure-activity relationship and cellular toxicity of specific Aβ domains in neuronal cell cultures.
• Antibody & Diagnostic Development: Serves as an antigen for the production and validation of antibodies targeting the Aβ(16-22) epitope in immunoassays.
• Material Science: Study of self-assembling peptide nanomaterials based on the amyloid core sequence for novel biomaterials.

Basic Information

Product Name	Amyloid β-Protein(16-22)
CAS No.	153247-41-7
Molecular Formula	C38H59N11O13
Molecular Weight	877.95 g/mol
Synonyms	Aβ(16-22); Amyloid β-Protein (16-22); Amyloid β-Peptide (16-22); KLVFFAE; H-Lys-Leu-Val-Phe-Phe-Ala-Glu-OH; Aβ16-22; Amyloid-β (16-22) fragment
EINECS	Contact for details

Quality Control

Every batch of Amyloid β-Protein(16-22) is synthesized and purified under stringent conditions to ensure the highest standards of identity, purity, and consistency. Our products undergo rigorous quality testing, including reversed-phase HPLC and mass spectrometry (MS), to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing purity, molecular weight confirmation, and chromatographic data is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Molecular Weight	877.95 g/mol (Confirmed by MS)
Amino Acid Sequence	H-Lys-Leu-Val-Phe-Phe-Ala-Glu-OH
Solubility	Soluble in water, DMSO, or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.