Description

Pth (18-48) (Human) is a synthetic peptide fragment corresponding to amino acid residues 18-48 of the human parathyroid hormone. This high-purity peptide is a critical research tool for studying calcium metabolism, bone biology, and endocrine signaling pathways. It is essential for pharmaceutical R&D, academic research, and diagnostic development in the fields of endocrinology and metabolic disorders. CAS No. 153238-99-4.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of parathyroid hormone (PTH) receptor binding, signal transduction, and structure-activity relationships (SAR).
• Pharmaceutical Development: Serves as a key intermediate or reference material in the development of PTH-based therapeutics for osteoporosis and hypoparathyroidism.
• Diagnostic Assay Calibration: Employed in the calibration and validation of immunoassays (e.g., ELISA, RIA) designed to detect and quantify PTH levels in clinical samples.
• Cell Culture & In Vitro Studies: Applied in cell-based assays to investigate the physiological effects of PTH on osteoblasts, renal cells, and other target tissues.
• Antibody Production: Utilized as an immunogen for generating specific antibodies against defined epitopes of the human parathyroid hormone.

Basic Information

Product Name	Pth (18-48) (Human)
CAS No.	153238-99-4
Molecular Formula	C145H238N44O45S2
Molecular Weight	~3327.8 g/mol
Synonyms	Parathyroid Hormone (18-48), human; hPTH (18-48); PTH 18-48 fragment; Parathyrin (18-48); PTH human fragment 18-48; N-terminal PTH fragment; Synthetic human PTH (18-48); PTH (1-84) fragment (18-48)
EINECS	Contact for details

Quality Control

Our Pth (18-48) (Human) is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot is characterized using advanced analytical techniques including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Composition	Within ±10% of theoretical
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.