Description

6-Hydroxytaxol is a key semi-synthetic derivative and metabolite of the potent anticancer agent Paclitaxel. This compound matters significantly as a crucial intermediate in pharmaceutical research and development, enabling the synthesis of novel taxane analogs with potentially improved therapeutic profiles. It is primarily needed by research institutions and pharmaceutical companies focused on oncology drug discovery, metabolite studies, and the development of next-generation chemotherapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical building block for the synthesis of novel taxane-based anticancer drugs and prodrugs.
• Metabolite Reference Standard: Used as an analytical standard in pharmacokinetic and metabolic studies of Paclitaxel.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to develop taxol derivatives with enhanced efficacy or reduced side effects.
• Biochemical Research: Utilized in studies investigating the mechanism of action of taxanes and their interaction with tubulin.
• Academic & Institutional R&D: A vital reagent for universities and research institutes exploring cancer biology and novel chemotherapeutic pathways.

Basic Information

Product Name	6-Hydroxytaxol
CAS No.	153212-75-0
Molecular Formula	C47H51NO15
Molecular Weight	869.91 g/mol
Synonyms	6α-Hydroxytaxol; 6α-Hydroxypaclitaxel; 2α,4α,6α,9α-Tetrahydroxy-4β,20-epoxy-1β,7β,10β,13α-tetraacetoxy-11β-benzoyloxy-5β,12β-dibenzoyloxytax-11-en-9-one; Paclitaxel, 6α-hydroxy-; 6-Hydroxy Paclitaxel; 6-OH-Taxol; 6α-OH-Paclitaxel
EINECS	Contact for details

Quality Control

Our 6-Hydroxytaxol is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, store desiccated at 2-8°C. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.