Description

Endothelin-1, Aba(1,15)- is a synthetic, biologically active peptide analog of the potent vasoconstrictor Endothelin-1, featuring aminoisobutyric acid (Aib) substitutions at positions 1 and 15. This modification enhances its metabolic stability, making it a critical research tool for studying endothelin receptor interactions and vascular physiology. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in cardiovascular disease research, drug discovery, and biochemical pathway analysis.

Application

• Biomedical Research: Used as a reference standard and agonist in studies of endothelin receptor (ETA and ETB) binding, signaling, and function.
• Drug Discovery & Development: Serves as a key pharmacological tool for high-throughput screening (HTS) and validation of novel endothelin receptor antagonists.
• Cardiovascular Physiology Studies: Employed in in vitro and ex vivo models to investigate vasoconstriction, blood pressure regulation, and related pathologies.
• Signal Transduction Research: Facilitates the study of G-protein coupled receptor (GPCR) mechanisms and intracellular calcium mobilization.
• Peptide Chemistry & Stability Studies: Acts as a model compound for analyzing the effects of Aib substitution on peptide conformation and protease resistance.
• Quality Control & Assay Development: Functions as a certified reference material (CRM) for calibrating bioassays and analytical methods in QC laboratories.

Basic Information

Product Name	Endothelin-1, Aba(1,15)-
CAS No.	153094-75-8
Molecular Formula	C109H159N27O32S5
Molecular Weight	2492.9 g/mol
Synonyms	[Aib1,15]-Endothelin-1; Endothelin-1 (Aib1,15); ET-1 (Aib1,15); [Aib1,15]ET-1; H-Aib-Ser-Cys-Ser-Cys-Asn-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bridges: Cys3-Cys11, Cys15-Cys21); 2-Aminoisobutyric Acid1,15-Endothelin-1; α-Aminoisobutyric Acid1,15-Endothelin-1
EINECS	Contact for details

Quality Control

Our Endothelin-1, Aba(1,15)- is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.