Description

(E)-4-Hydroxy Tamoxifen o-β-D-Glucuronide is a major, water-soluble Phase II metabolite of the selective estrogen receptor modulator (SERM) tamoxifen, formed via glucuronidation. This compound is of critical importance for pharmaceutical research and development, serving as a key reference standard and analytical tool for studying tamoxifen metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in oncology drug development and clinical pharmacology studies.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the qualitative and quantitative analysis of tamoxifen and its metabolites in biological matrices.
• Metabolite Identification & Pharmacokinetics: Essential for studying the metabolic pathways, clearance mechanisms, and exposure levels of tamoxifen in preclinical and clinical studies.
• Bioanalytical Method Development: Used to develop, validate, and calibrate LC-MS/MS, HPLC, and other analytical methods for accurate quantification in plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: A critical reagent for investigating the absorption, distribution, metabolism, and excretion (ADME) profile of tamoxifen.
• Clinical Research & Therapeutic Drug Monitoring (TDM): Supports research into tamoxifen's efficacy, toxicity, and personalized dosing strategies based on metabolic phenotypes.
• Quality Control in Manufacturing: Serves as a system suitability standard in the quality control of tamoxifen active pharmaceutical ingredient (API) and finished drug products.

Basic Information

Product Name	(E)-4-Hydroxy Tamoxifen o-β-D-Glucuronide
CAS No.	152764-51-7
Molecular Formula	C34H41NO9
Molecular Weight	607.70 g/mol
Synonyms	4-Hydroxytamoxifen O-β-D-Glucuronide; (E)-4-Hydroxytamoxifen Glucuronide; (Z)-4-Hydroxytamoxifen Glucuronide (Isomer); 4-OHT-Gluc; Endoxifen Glucuronide (related metabolite); Tamoxifen Metabolite Standard; trans-4-Hydroxytamoxifen Glucuronide; N-Desmethyl-4-hydroxytamoxifen Glucuronide (related metabolite)
EINECS	Contact for details

Quality Control

Our (E)-4-Hydroxy Tamoxifen o-β-D-Glucuronide is manufactured under strict quality systems suitable for research and analytical use. Each batch undergoes rigorous analytical testing including HPLC, LC-MS, and NMR to confirm identity, purity, and stability. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment. We support compliance with ICH guidelines for stability and method validation.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the product to equilibrate to room temperature in the sealed container before opening to prevent moisture condensation. The material should be handled in a controlled environment to ensure integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0% (Area %)
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.