Description

D-Proline, 4-Hydroxy-2-Methyl-, (4S)-Rel- (9Ci) is a high-purity, non-proteinogenic amino acid derivative characterized by its unique stereochemistry and functional groups. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the construction of complex molecules with precise stereocontrol. It is essential for research and development in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs), peptide mimetics, and chiral ligands.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and production of novel therapeutic agents, including enzyme inhibitors and receptor modulators.
• Peptidomimetics & Bioactive Peptide Synthesis: Used to introduce conformational constraints and enhance metabolic stability in peptide-based drug design.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands and organocatalysts used in stereoselective chemical transformations.
• Agrochemical Research: Employed in the development of new chiral pesticides and herbicides with improved efficacy and selectivity.
• Chemical Biology & Proteomics: Utilized as a molecular probe or labeled amino acid analog in biochemical studies and protein engineering.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	D-Proline, 4-Hydroxy-2-Methyl-, (4S)-Rel- (9Ci)
CAS No.	152722-89-9
Molecular Formula	C6H11NO3
Molecular Weight	145.16 g/mol
Synonyms	(4S)-rel-4-Hydroxy-2-methyl-D-proline; 4-Hydroxy-2-methyl-D-proline; (2R,4S)-4-Hydroxy-2-methylpyrrolidine-2-carboxylic acid; D-4-Hydroxy-2-methylproline; 152722-89-9; (4S)-4-Hydroxy-2-methyl-D-proline; rel-(4S)-4-Hydroxy-2-methyl-D-proline
EINECS	Contact for details

Quality Control

Every batch of D-Proline, 4-Hydroxy-2-Methyl-, (4S)-Rel- (9Ci) is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure compliance with exacting standards for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.