Description

Fibrinogen Bern I CAS NO 152618-35-4 is a highly purified, functional plasma protein fraction, specifically the Bern I variant, which is critical for the final stages of the blood coagulation cascade. Its primary value lies in its essential role as a substrate for thrombin, forming the fibrin clot matrix vital for hemostasis and wound healing. This product is indispensable for research and development in hemostasis diagnostics, biochemical research, and the development of hemostatic agents and biomaterials.

Application

• Hemostasis and Thrombosis Research: Fundamental substrate for in vitro studies of clot formation, stability, and lysis.
• Diagnostic Reagent Manufacturing: A key component in the calibration and production of clinical assays for fibrinogen activity and related coagulation factors.
• Biomaterial Development: Used in the engineering of fibrin-based scaffolds, sealants, and adhesives for surgical and tissue regeneration applications.
• Quality Control & Standardization: Serves as a reference standard in pharmaceutical QC labs for validating hemostatic products.
• Enzyme Kinetic Studies: Employed to study the kinetics and specificity of thrombin and other serine proteases involved in coagulation.
• Cell Culture & Tissue Engineering: Provides a physiological matrix to support cell growth, differentiation, and 3D tissue modeling.

Basic Information

Product Name	Fibrinogen Bern I
CAS No.	152618-35-4
Molecular Formula	Contact for details
Molecular Weight	~340 kDa (Heterodimer)
Synonyms	Factor I (Bern I variant); Coagulation Factor I; Fibrinogen (Human); Plasma Fibrinogen; Fibrinogen, Human; Bern I Fibrinogen; FGA/FGB/FGG Complex; Fibrinogen Gamma Chain; Fibrinogen Beta Chain; Fibrinogen Alpha Chain
EINECS	Contact for details

Quality Control

Our Fibrinogen Bern I is produced and tested under stringent quality management systems. Each lot undergoes comprehensive analytical testing to ensure high functional activity, purity, and consistency. Specifications are aligned with research-grade standards, and a detailed Certificate of Analysis (COA) providing data on clottable protein, activity, and purity is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Avoid repeated freeze-thaw cycles. Allow to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solid
Identification (Functional)	Forms a firm, stable clot upon addition of thrombin
Clottable Protein	≥ 90% (by weight)
Purity (SDS-PAGE)	Major bands corresponding to Aα, Bβ, and γ chains
Solubility	Clear, slightly opalescent solution in appropriate buffer
Moisture (Karl Fischer)	< 5.0 %
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.