Description

ω-Grammotoxin Sia is a specialized, high-purity neurotoxin peptide derived from the venom of the spider *Grammostola spatulata*. This compound matters as a potent and selective inhibitor of N-type voltage-gated calcium channels (Cav2.2), making it an essential research tool for neuropharmacological studies. It is primarily needed by pharmaceutical R&D teams, academic neuroscientists, and biotechnology companies focused on pain research, neurological disorders, and ion channel characterization.

Application

• Neuroscience Research: A critical tool for studying the role of N-type calcium channels in synaptic transmission, neurotransmitter release, and neuronal excitability.
• Pain Pathway Analysis: Used in preclinical research to investigate novel analgesic targets and mechanisms for chronic pain management.
• Ion Channel Pharmacology: Serves as a selective blocker in electrophysiology assays (e.g., patch-clamp) to characterize Cav2.2 channel function and screen potential modulators.
• Drug Discovery: Employed in target validation and high-throughput screening (HTS) campaigns for developing new classes of neuropathic pain therapeutics.
• Cellular Signaling Studies: Facilitates the dissection of calcium-dependent signaling cascades in neuronal and endocrine cells.
• Biochemical Assay Standard: Can be used as a reference standard in competitive binding assays and for calibrating functional activity tests.

Basic Information

Product Name	ω-Grammotoxin Sia
CAS No.	152617-90-8
Molecular Formula	C185H273N55O52S6
Molecular Weight	~4090.7 g/mol
Synonyms	Grammotoxin SIA; ω-Grammotoxin SIA; Grammotoxin SI; GsAFII; GsAF-2; SNX-325; Synthetic ω-Grammotoxin SIA; Voltage-gated calcium channel blocker ω-Grammotoxin SIA; N-type calcium channel blocker from Grammostola spatulata
EINECS	Contact for details

Quality Control

Our ω-Grammotoxin Sia is produced and controlled under stringent conditions suitable for research use. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. We provide full traceability and a detailed Certificate of Analysis (COA) with each shipment, ensuring reliable performance and reproducibility in your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store the lyophilized powder at -20°C or below. For long-term storage, consider -80°C. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure the vial is equilibrated to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Biological Activity (IC50)	Specified on COA
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.