Description

Boc-Tyr(Bzl)-Chloromethylketone is a specialized protected amino acid derivative designed for advanced peptide synthesis and biochemical research. This compound serves as a critical building block and a potent, irreversible serine protease inhibitor, enabling precise control over enzymatic activity and molecular assembly. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and organic chemistry who require high-purity intermediates for creating novel therapeutic agents and research tools.

Application

• Peptide Synthesis Intermediate: A key protected building block for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Protease Inhibitor Research: Acts as an active site-directed chloromethyl ketone inhibitor for studying the mechanism and function of serine proteases like trypsin, chymotrypsin, and thrombin.
• Pharmaceutical Development: Used in the research and development of protease-targeted drugs for conditions such as inflammation, thrombosis, and cancer.
• Biochemical Probe: Employed to label and inactivate specific proteases in complex biological systems for pathway analysis and target validation.
• Chemical Biology Tool: Facilitates the study of protein-protein interactions and enzyme kinetics through irreversible inhibition.
• Reference Standard: Serves as a high-purity analytical standard for quality control in peptide API manufacturing and related research.

Basic Information

Product Name	Boc-Tyr(Bzl)-Chloromethylketone
CAS No.	152438-62-5
Molecular Formula	C22H26ClNO5
Molecular Weight	419.90 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-O-benzyl-L-tyrosyl chloromethyl ketone; Boc-Tyr(Bzl)-CMK; Boc-L-Tyrosine(O-Benzyl) Chloromethyl Ketone; tert-Butyloxycarbonyl-O-benzyl-L-tyrosyl chloromethyl ketone; N-Boc-O-benzyl-L-tyrosine chloromethyl ketone; Boc-Tyr(Bzl)-CH2Cl; Protease Inhibitor (Chloromethyl Ketone derivative of Boc-Tyr(Bzl))
EINECS	Contact for details

Quality Control

Our Boc-Tyr(Bzl)-Chloromethylketone is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR). Certificates of Analysis (COA) detailing all specifications are provided to support your research and cGMP-compliant manufacturing needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.