Description

N(2)-(Deoxyguanosin-8-Yl)-2-Amino-3,8-Dimethylimidazo(4,5-F)Quinoxaline 3',5'-Diphosphate is a chemically modified nucleoside adduct, specifically a phosphate derivative of a heterocyclic aromatic amine-DNA lesion. This compound is of significant value as a critical reference standard and research tool in the fields of genetic toxicology and molecular carcinogenesis. It is primarily needed by academic research institutions, pharmaceutical R&D laboratories, and contract research organizations (CROs) focused on studying DNA damage, mutagenesis, and the metabolic activation of food-borne heterocyclic amines.

Application

• Biomarker Research: Used as an analytical standard for the precise quantification of specific DNA adducts formed by heterocyclic aromatic amines (HAAs) like MeIQx in biological samples.
• Toxicology Studies: Essential for in vitro and in vivo studies investigating the genotoxic potency, metabolic pathways, and repair mechanisms associated with cooked-food mutagens.
• Method Development & Validation: Serves as a high-purity calibrant in advanced analytical techniques such as LC-MS/MS, 32P-postlabeling, and HPLC with fluorescence detection to develop sensitive assays for DNA damage.
• Cancer Research: Facilitates studies on the role of specific DNA lesions in the initiation of chemical carcinogenesis, aiding in risk assessment.
• Standards Manufacturing: Used by producers of certified reference materials (CRMs) to create traceable standards for food safety and environmental monitoring laboratories.

Basic Information

Product Name	N(2)-(Deoxyguanosin-8-Yl)-2-Amino-3,8-Dimethylimidazo(4,5-F)Quinoxaline 3',5'-Diphosphate
CAS No.	152432-43-4
Molecular Formula	C₂₄H₂₈N₉O₁₂P₂
Molecular Weight	728.48 g/mol
Synonyms	dG-C8-MeIQx 3',5'-diphosphate; N-(Deoxyguanosin-8-yl)-MeIQx 3',5'-bisphosphate; 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline-deoxyguanosine 3',5'-diphosphate adduct; MeIQx-DNA adduct (diphosphate form); 3',5'-Bisphosphorylated dG-MeIQx; 8-(2-Amino-3,8-dimethylimidazo[4,5-f]quinoxalin-3-ium-1-yl)-2'-deoxyguanosine 3',5'-diphosphate
EINECS	Contact for details

Quality Control

Our production of this advanced biochemical standard adheres to rigorous quality protocols. Each batch is characterized using a combination of spectroscopic and chromatographic techniques to ensure structural identity and high purity. Certificates of Analysis (COA) are provided, detailing batch-specific results for purity, identity, and impurity profile. While produced as a research chemical, our quality systems ensure traceability and consistency critical for scientific reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M-H]⁻
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.