Description

α-Hydroxysalmeterol is a key pharmaceutical intermediate and reference standard, identified by CAS number 152405-02-2. This compound is of significant importance in the development and quality control of advanced respiratory therapeutics. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the synthesis and analysis of long-acting β-2 adrenergic agonists. Its precise chemical structure makes it essential for ensuring product efficacy and regulatory compliance in drug development pipelines.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of Salmeterol and related bronchodilator medications.
• Analytical Reference Standard: Used in HPLC, GC-MS, and other chromatographic methods for quality assurance and impurity profiling of active pharmaceutical ingredients (APIs).
• Metabolite Studies: Serves as a reference compound in pharmacokinetic and metabolic pathway research for respiratory drugs.
• Process Development & Validation: Employed in the development and scaling of manufacturing processes within GMP environments.
• Regulatory Submissions: Provides certified material for stability testing and documentation required by agencies like the FDA and EMA.
• Academic & Contract Research: Utilized in university and CRO settings for pharmacological research and method development.

Basic Information

Product Name	α-Hydroxysalmeterol
CAS No.	152405-02-2
Molecular Formula	C25H37NO4
Molecular Weight	415.57 g/mol
Synonyms	α-Hydroxysalmeterol; Salmeterol Impurity; Salmeterol Hydroxy Impurity; 1-Hydroxy-4-[1-hydroxy-2-[[6-(4-phenylbutoxy)hexyl]amino]ethyl]benzene; 4-[1-Hydroxy-2-({6-[4-(phenyl)butoxy]hexyl}amino)ethyl]benzene-1,2-diol; Salmeterol Related Compound; (RS)-α-Hydroxysalmeterol
EINECS	Contact for details

Quality Control

Our α-Hydroxysalmeterol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of specified impurities. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with the stringent requirements of pharmaceutical development and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect the light-sensitive material from degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0% w/w
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.