Description

5-o-Methyldihydrotetrabenazine is a high-purity synthetic organic compound belonging to the class of tetrabenazine derivatives. This compound serves as a critical intermediate or reference standard in advanced pharmaceutical research and development, particularly for neurological applications. It is primarily sought by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel vesicular monoamine transporter 2 (VMAT2) inhibitors and related central nervous system (CNS) active compounds.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research for tetrabenazine and its analogs.
• Biochemical Research: A tool compound for investigating neurotransmitter regulation, synaptic function, and related neurological mechanisms in vitro.
• Process Chemistry: Serves as a precursor in the scale-up and optimization of active pharmaceutical ingredient (API) manufacturing processes.

Basic Information

Product Name	5-o-Methyldihydrotetrabenazine
CAS No.	152404-97-2
Molecular Formula	C20H27NO3
Molecular Weight	329.44 g/mol
Synonyms	5-O-Methyldihydrotetrabenazine; 9,10-Dimethoxy-5-(2-methylpropyl)-2,3,4,5,6,7-hexahydro-1H-3-benzazepin-1-one; Dihydrotetrabenazine 5-O-Methyl Ether; 5-OMe-DHTBZ; 5-Methoxy DHTBZ; Tetrabenazine Derivative; 1H-3-Benzazepin-1-one, 9,10-dimethoxy-5-(2-methylpropyl)-2,3,4,5,6,7-hexahydro-
EINECS	Contact for details

Quality Control

Our 5-o-Methyldihydrotetrabenazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis to ensure it meets stringent research-grade specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.